Leo Sternbach and the benzodiazepines 60 years on: A revolutionary treatment for anxiety disorders

Leo Sternbach and the benzodiazepines 60 years on: A revolutionary treatment for anxiety disorders

[Display omitted] •Until the 1960s, the treatment of anxiety disorders was quite limited.•Leo Sternbach was the chemist who first synthesized a benzodiazepine.•Benzodiazepines helped in identifying pharmacological targets for treating anxiety.•The current goal is to create specific agonists for the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmacological research 2024-09, Vol.207, p.107310, Article 107310
Hauptverfasser: Junkes, Larissa, Mendlowicz, Mauro V., Shader, Richard, Nardi, Antonio E.
Format: Artikel
Sprache:eng
Schlagworte:
Benzodiazepines
Chemistry, Pharmaceutical
History of Medicine
Pharmacology
Psychopharmacology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:[Display omitted] •Until the 1960s, the treatment of anxiety disorders was quite limited.•Leo Sternbach was the chemist who first synthesized a benzodiazepine.•Benzodiazepines helped in identifying pharmacological targets for treating anxiety.•The current goal is to create specific agonists for the GABA-A receptor α2-subtype.
ISSN:1043-6618
1096-1186
1096-1186
DOI:10.1016/j.phrs.2024.107310