Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss

The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history. During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study di...

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Veröffentlicht in:	BMC research notes 2018-04, Vol.11 (1), p.233-233, Article 233
Hauptverfasser:	Sah, Anil Kumar, Shrestha, Nisha, Joshi, Pratikshya, Lakha, Renu, Shrestha, Sweta, Sharma, Laxmi, Chandra, Avinash, Singh, Neetu, Kc, Yuvraj, Rijal, Bhola
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Habitual - genetics Adult Age groups Couples Cross-Sectional Studies DNA methylation Enzymes Female Gene polymorphism Genetic aspects Genetic polymorphisms Genotype & phenotype Gynecology Health aspects Humans Male Menstruation Methylenetetrahydrofolate reductase Methylenetetrahydrofolate reductase (MTHFR) Methylenetetrahydrofolate Reductase (NADPH2) - genetics Miscarriage Mutation Nepal Obstetrics PCR–RFLP Polymorphism Polymorphism, Genetic Pregnancy Recurrent miscarriage Recurrent pregnancy loss Research Note Risk factors Social aspects Womens health Young Adult
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Zusammenfassung:	The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history. During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study did not find any association between MTHFR C677T polymorphism and gender (p > 0.05), gestational period (p > 0.05), geographical region (p > 0.05) and menstrual history (p > 0.05). However, significant association was seen between MTHFR C677T polymorphism and number of losses (p
ISSN:	1756-0500 1756-0500
DOI:	10.1186/s13104-018-3321-x