Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery

Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery

To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery. This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain inter...

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Veröffentlicht in:Journal of pain research 2016-01, Vol.9, p.1101-1107
Hauptverfasser: Parsons, Bruce, Zhu, Qijiang, Xie, Li, Li, Chunming, Cheung, Raymond
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics
Analysis
Anesthesiology
Care and treatment
Clinical trials
Constipation
Gynecologic surgery
Gynecology
Narcotics
Nausea
Nonsteroidal anti-inflammatory drugs
Original Research
Pain
Pain management
Pain, Postoperative
Parecoxib
Patients
Postoperative pain
Sodium
Surgery
Surgical outcomes
Systematic review
Variance analysis
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Beschreibung
Zusammenfassung:To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery. This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain interference with function, opioid use, occurrence of opioid-related symptoms, and Patient/Physician Global Evaluation of Study Medication were compared between placebo and PAR/VAL treatment groups in the days following surgery. Pain scores were reduced in the PAR/VAL group (n=98), relative to placebo (n=97), on Day 2 (-21%,
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S111733