5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling

A series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds and all intermediates were elucidated by spectroscopic analysis. Furthermore, pharmacokinetic and drug-like computations...

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Veröffentlicht in:	MolBank 2024-02, Vol.2024 (1), p.M1779
Hauptverfasser:	Giraldo-Arroyave, Laura, Yepes, Andrés F, Cardona-Galeano, Wilson
Format:	Artikel
Sprache:	eng
Schlagworte:	5-FU Analysis Care and treatment Chemical synthesis chromone click chemistry Colorectal cancer Coumarin Coumarins drug-likeness modeling Drugs Fluorouracil Heterocyclic compounds hybrid compounds Identification and classification Methods Permeability Pharmacokinetics Properties Proteins Structure Toxicity
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Zusammenfassung:	A series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds and all intermediates were elucidated by spectroscopic analysis. Furthermore, pharmacokinetic and drug-like computations taken together indicated that the novel hybrids have a strong possibility to advance to further biological studies.
ISSN:	1422-8599 1422-8599
DOI:	10.3390/M1779