Prognostic role of pre-treatment C-reactive protein/albumin ratio in esophageal cancer: a meta-analysis

In recent years, the role of pre-treatment C-reactive protein/albumin ratio (CAR) in prognosis of esophageal cancer (EC) has been investigated by several studies. This meta-analysis aimed to provide a more accurate and objective assessment of the prognostic value of pre-treatment CAR in EC. Studies...

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Veröffentlicht in:	BMC cancer 2019-11, Vol.19 (1), p.1161-9, Article 1161
Hauptverfasser:	Liu, Zhenhua, Shi, Hongtai, Chen, Longyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant chemotherapy Albumin Automobiles Bias Biomarkers Biomarkers, Tumor - analysis C-reactive protein C-Reactive Protein - analysis C-reactive protein/albumin ratio Cancer Cancer therapies Chemotherapy Clinical trials Esophageal cancer Esophageal Neoplasms - blood Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophagus Humans Malnutrition Medical prognosis Medical research Meta-analysis Operating systems (Software) Patients Predictive Value of Tests Prognosis Proportional Hazards Models Proteins Sensitivity analysis Serum Albumin - analysis Studies Survival Survival Analysis Tumors
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Zusammenfassung:	In recent years, the role of pre-treatment C-reactive protein/albumin ratio (CAR) in prognosis of esophageal cancer (EC) has been investigated by several studies. This meta-analysis aimed to provide a more accurate and objective assessment of the prognostic value of pre-treatment CAR in EC. Studies assessing the role of pre-treatment CAR in prognosis of EC were searched from PubMed, Embase and the Cochrane Library (last update by April 16, 2019). The hazard ratios (HRs) of CAR and the corresponding 95% CIs for overall survival (OS) or cancer-specific survival (CSS) in EC were extracted for pooled analysis. A total of eight observational studies including 2255 patients were collected. The pooled analysis showed that high CAR was related to worse OS in EC (pooled HR = 1.81; 95% CI = 1.40-2.35; P
ISSN:	1471-2407 1471-2407
DOI:	10.1186/s12885-019-6373-y