Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis

Worldwide, up to 20% of children and adolescents experience mental disorders, which are the leading cause of disability in young people. Research shows that serum zonulin levels are associated with increased intestinal permeability (IP), affecting neural, hormonal, and immunological pathways. This s...

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Veröffentlicht in:	Nutrients 2020-07, Vol.12 (7), p.1982
Hauptverfasser:	Asbjornsdottir, Birna, Snorradottir, Heiddis, Andresdottir, Edda, Fasano, Alessio, Lauth, Bertrand, Gudmundsson, Larus S, Gottfredsson, Magnus, Halldorsson, Thorhallur Ingi, Birgisdottir, Bryndis Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent adolescents Anxiety disorders Ataxia Attention Deficit Disorder with Hyperactivity - blood Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder - blood Behavior Bibliographic data bases Bipolar disorder Blood-brain barrier Blood-Brain Barrier - metabolism Brain research Child Children Female Gluten haptoglobin Haptoglobins Humans Immune response Immune system Immunology Inflammation Intestinal Mucosa - metabolism intestinal permeability Intestine Literature reviews Male Mental disorders Mental health Meta-analysis Microbiota Neurodevelopmental disorders Neurodevelopmental Disorders - blood Observational studies Observational Studies as Topic Obsessive compulsive disorder Obsessive-Compulsive Disorder - blood Pathogenesis Peptides Permeability Plasma levels Protein Precursors - blood Review Schizophrenia Signs and symptoms Subject heading schemes Systematic review Teenagers Young adults zonulin
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Zusammenfassung:	Worldwide, up to 20% of children and adolescents experience mental disorders, which are the leading cause of disability in young people. Research shows that serum zonulin levels are associated with increased intestinal permeability (IP), affecting neural, hormonal, and immunological pathways. This systematic review and meta-analysis aimed to summarize evidence from observational studies on IP in children diagnosed with mental disorders. The review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search of the Cochrane Library, PsycINFO, PubMed, and the Web of Science identified 833 records. Only non-intervention (i.e., observational) studies in children (
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu12071982