Pharmacological Analyses of the Mechanisms of Morinda officinalis How. in the Treatment of Alzheimer's Disease

Objective: To analyze the potential targets and mechanism of action underlying the therapeutic action of Morinda officinalis How. against Alzheimer's disease (AD) based on network pharmacology, molecular docking, and gene expression omnibus (GEO) data. Methods: Using the traditional chinese medicine systematic pharmacology database and analysis platform (TCMSP), the main active components of Morinda officinalis were identified, and the targets of Morinda officinalis were obtained via SwissTargetPrediction. AD-related targets were obtained from DrugBank, PathCard, Chemogenomic Database, and PubChem databases. Then, Venn diagram was used to obtain the common targets of both Morinda officinalis and AD. Cytoscape 3.8.0 was used to construct ''component-target'' network diagrams of the targets. The protein-protein interaction (PPI) network diagrams, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways of the targets were analyzed. The molecular docking of key components and tar