Comparison between clinical features and prognosis of malignancy- and non-malignancy-associated pediatric hemophagocytic lymphohistiocytosis

The differences between the clinical characteristics and survival time in malignancy- and non-malignancy-associated secondary hemophagocytic lymphohistiocytosis (HLH) are unclear. Here, we describe the clinical characteristics, prognostic factors, and survival outcomes of malignancy-associated HLH c...

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Veröffentlicht in:	BMC pediatrics 2019-11, Vol.19 (1), p.468-468, Article 468
Hauptverfasser:	Pan, Hua, Huo, Yongmin, Sun, Lirong
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Albumin Antigens Aspartate Bacterial infections Bone marrow Cancer Chemotherapy Child Child health Disease Disseminated intravascular coagulation Gallbladder diseases Hematopoietic stem cell transplantation Hematopoietic stem cells Hemoglobins Hemophagocytic lymphohistiocytosis Immunoglobulins Infections Leukemia Lymphatic diseases Lymphoma Medical prognosis Mortality Multivariate analysis Patients Pediatrics Perforin Prognosis Rankings Stem cell transplantation Stem cells Surgery Variables
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Zusammenfassung:	The differences between the clinical characteristics and survival time in malignancy- and non-malignancy-associated secondary hemophagocytic lymphohistiocytosis (HLH) are unclear. Here, we describe the clinical characteristics, prognostic factors, and survival outcomes of malignancy-associated HLH compared to that of non-malignancy-associated HLH. We retrospectively analyzed 91 pediatric patients with HLH (age 5 (p = 0.001), albumin
ISSN:	1471-2431 1471-2431
DOI:	10.1186/s12887-019-1702-5