Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy

Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with...

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Veröffentlicht in:Frontiers in immunology 2021-08, Vol.12
Hauptverfasser: Bošnjak, Berislav, Odak, Ivan, Ritter, Christiane, Stahl, Klaus, Graalmann, Theresa, Steinbrück, Lars, Blasczyk, Rainer, Falk, Christine S., Schulz, Thomas F., Wedemeyer, Hans Heinrich, Cornberg, Markus, Ganser, Arnold, Förster, Reinhold, Koenecke, Christian
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Sprache:eng
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Zusammenfassung:Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.721738