Systematic review and Meta-analysis of intradialytic hypotension incidence in Chinese maintenance hemodialysis patients

ObjectiveTo conduct a systematic review and Meta-analysis on the prevalence and incidence of intradialytic hypotension （IDH） among maintenance hemodialysis patients in China. MethodsA comprehensive search was performed across multiple databases using a combination of MeSH terms and free-text keywords. The cut-off period lasted from database inception until August 1， 2023. Studies fulfilling the inclusion criteria were selected and Meta-analysis of single-group proportions was conducted. Results A total of 42 studies involving 12263 patients were included. The pooled prevalence of IDH under a random-effect model was 35.5%（95%CI：30.6～40.7） with heterogeneity （I2 = 96.5%，PQ＜0.001，PEgger＜0.001，PBegger = 0.036）. The incidence of IDH was 7.2%（95%CI：3.3～15.1）， with heterogeneity （I2 = 100%，PQ＜0.001，PEgger = 0.064，PBegger = 0.393）. Conclusion A review of the literature spanning 23 years in China has revealed considerable variability in the definitions of IDH across many studies， leading to significant differences in