The role of GPR56/ADGRG1 in health and disease

GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated...

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Veröffentlicht in:	Biomedical Journal 2021-10, Vol.44 (5), p.534-547
Hauptverfasser:	Singh, Abhishek Kumar, Lin, Hsi-Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion GPCR Cell Transformation, Neoplastic Depression G protein Humans Ligand Malformations of Cortical Development Receptors, G-Protein-Coupled - physiology Review Signaling
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Beschreibung
Zusammenfassung:	GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.
ISSN:	2319-4170 2320-2890
DOI:	10.1016/j.bj.2021.04.012