The Effect of Intense and Moderate Interval Aerobic Exercise and Curcumin Consumption on the Gene Expression of c-Kit in Stem Cells of Old Rats Heart

Background & Objectives: C-kit+ cells are the most important cardiac stem cells and have Myogenic and Vasculogenic properties. Exercise training tends to stimulate these cells. This study aims to investigate the effect of intense and moderate interval aerobic training and curcumin consumption on the gene expression of c-Kit stem cells of heart in old rats. Materials &Methods: 35 Wistar old female rats of about two years were randomly divided into 5 groups: control, saline, curcumin, moderate training + curcumin and intense training + curcumin. 30 mg Curcumin for each kg of their body weight was given by gavage to the rats in experimental groups 3 days a week. The saline group was given the same amount of saline. Both groups underwent interval aerobic training on treadmill 3 sessions per week for 8 weeks, with high and medium intensity. 48 hours after the last training and gavage, c-Kit gene expression for cardiac stem cells was measured. Results: The results indicated that in each Curcumin group, c-Kit level increased significantly compared to that of the control group (P=0.003). The mean of moderate exercise + curcumin group was significantly higher than the mean of curcumin, saline and control groups (P