Intermediate vancomycin susceptibility in a community-associated MRSA clone

We describe a case of treatment failure caused by a strain of USA300 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with intermediate susceptibility to vancomycin and reduced susceptibility to daptomycin. The strain was isolated from the bone of a 56-year-old man with lumbar...

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Veröffentlicht in:	Emerging infectious diseases 2007-03, Vol.13 (3), p.491-493
Hauptverfasser:	Graber, Christopher J, Wong, Margaret K, Carleton, Heather A, Perdreau-Remington, Françoise, Haller, Barbara L, Chambers, Henry F
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Case studies Community-acquired infections Community-Acquired Infections - drug therapy Community-Acquired Infections - microbiology daptomycin Daptomycin - pharmacology Diagnosis Dispatch Drug resistance in microorganisms Health aspects Humans Lumbar Vertebrae - microbiology Male Methicillin - pharmacology Methicillin Resistance Microbial Sensitivity Tests Middle Aged Osteomyelitis - drug therapy Osteomyelitis - microbiology Panton-Valentine leukocidin Patient outcomes Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Thrombophlebitis - drug therapy Treatment Outcome Vancomycin - pharmacology Vancomycin - therapeutic use vancomycin resistance
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Beschreibung
Zusammenfassung:	We describe a case of treatment failure caused by a strain of USA300 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with intermediate susceptibility to vancomycin and reduced susceptibility to daptomycin. The strain was isolated from the bone of a 56-year-old man with lumbar osteomyelitis after a 6-week treatment course of vancomycin for catheter-associated septic thrombophlebitis.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1303.060960