A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences

There are great diversities of clinical phenotypes among the various familial Alzheimer's disease (FAD) families. We aimed to systematically review all the previously reported cases of FAD and to perform comparisons between Asian and white patients. In this regard, we collected individual-level...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the Formosan Medical Association 2016-02, Vol.115 (2), p.67-75
Hauptverfasser:	Shea, Yat-Fung, Chu, Leung-Wing, Chan, Angel On-Kei, Ha, Joyce, Li, Yan, Song, You-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - ethnology Alzheimer Disease - genetics Amyloid beta-Protein Precursor - genetics amyloid precursor protein Asian Continental Ancestry Group autosomal dominant familial Alzheimer's disease Humans Internal Medicine Mutation Pedigree presenilin-1 Presenilin-1 - genetics presenilin-2 Presenilin-2 - genetics Taiwan
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	There are great diversities of clinical phenotypes among the various familial Alzheimer's disease (FAD) families. We aimed to systematically review all the previously reported cases of FAD and to perform comparisons between Asian and white patients. In this regard, we collected individual-level data from 658 pedigrees. We found that patients with presenilin 1 ( PSEN1 ) mutations had the earliest age of onset (AOO; 43.3 ± 8.6 years, p
ISSN:	0929-6646
DOI:	10.1016/j.jfma.2015.08.004