Role of serum cytokeratin 19 fragment (Cyfra 21.1) as a prognostic biomarker in patients with differentiated thyroid cancer

Role of serum cytokeratin 19 fragment (Cyfra 21.1) as a prognostic biomarker in patients with differentiated thyroid cancer

Differentiated thyroid cancers (DTC) account for up to 85% of thyroid cancers and generally display an excellent prognosis. However, in a minority of cases, DTC progress toward less differentiated phenotypes leading to distant metastases and even disease-related deaths. Circulating biomarkers are wa...

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Veröffentlicht in:Scientific reports 2017-08, Vol.7 (1), p.7359-7, Article 7359
Hauptverfasser: Giovanella, L., Imperiali, M., Trimboli, P.
Format: Artikel
Sprache:eng
Schlagworte:
692/163/2743/1459/1843
692/4028/67/1857
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - blood
Biomarkers, Tumor
Cytokeratin
Female
Health risks
Humanities and Social Sciences
Humans
Kaplan-Meier Estimate
Keratin-19 - blood
Male
Medical prognosis
Metastases
Middle Aged
multidisciplinary
Multivariate analysis
Neoplasm Grading
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Risk assessment
Science
Science (multidisciplinary)
Thyroglobulin
Thyroglobulin - blood
Thyroid
Thyroid cancer
Thyroid gland
Thyroid Neoplasms - blood
Thyroid Neoplasms - mortality
Thyroid Neoplasms - pathology
Young Adult
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Zusammenfassung:Differentiated thyroid cancers (DTC) account for up to 85% of thyroid cancers and generally display an excellent prognosis. However, in a minority of cases, DTC progress toward less differentiated phenotypes leading to distant metastases and even disease-related deaths. Circulating biomarkers are warranted to complement the gold standard DTC marker thyroglobulin (Tg) in identifying and monitoring such cases. We measured serum Tg and Cyfra 21.1 6 to 12 months after primary treatment in 473 DTC patients. A complete response of Tg was related to an excellent outcome in all cases. Among patients with incomplete Tg response Cyfra 21.1 levels
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-07915-0