Primary adenosquamous carcinoma of the liver

Abdominal computed tomography showed a mass located in the left liver, and a space‐occupying lesion was found in the left hepatic duct along with dilated distal bile ducts, A. Structure of adenosquamous carcinoma: adenocarcinoma cells are arranged in a tubular pattern, and squamous carcinoma cells are nested (hematoxylin and eosin staining, B). Some scholars believe that chronic inflammation and continuous stimulation of various congenital biliary cysts can cause metaplastic changes of the bile duct epithelium, which leads to the occurrence of liver ASC. [...]ASC of the liver is considered to be a rare subtype of cholangiocarcinoma (CCC). While alpha fetal protein (AFP), as a typical tumor marker of HCC, is seldom expressed. [...]tumor markers may provide reference for early detection and disease monitoring of hepatic ASC.