Implications for comorbidities, maternal smoking during pregnancy, and inflammation in current smokers

•Smokers presented higher prevalence of major depressive disorder and alcohol problems.•Smokers showed lower levels of leptin, higher levels of HDL-c and higher castelli indexes.•Maternal smoking during pregnancy was significantly more frequent among smokers.•Heavy smokers had higher levels of sTNFR1 than light-smokers.•Smokers showed higher levels of TNF-alfa and its receptors (sTNFR1 and 2) than non-smokers. Evaluate comorbidities, childhood abuse, and inflammation in current heavy-smokers compared to light-smokers and never-smokers. Current-Smokers (n = 129) and never-smokers (n = 85) were screened for the use of alcohol, tobacco, and other substances, and assessed for nicotine dependence and childhood trauma. Tumor necrosis factor alpha (TNF-α) and its receptors (sTNFR1 and sTNFR2), leptin, lipid hydroperoxide, and lipid profile biomarkers were measured after overnight fasting. Current-smokers presented higher prevalence of major depressive disorder (PR = 1.79, CI 95% [1.36–2.37], p