TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen r...

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Veröffentlicht in:iScience 2020-03, Vol.23 (3), p.100937-100937, Article 100937
Hauptverfasser: Roy Chattopadhyay, Nabanita, Chatterjee, Koustav, Tiwari, Nikhil, Chakrabarti, Sudipta, Sahu, Sushil Kumar, Deb Roy, Sankar, Ghosh, Arijit, Reddy, R. Rajendra, Das, Piyanki, Mal, Sudipa, Karnar, Basab Bijay, Das, Ashok Kumar, Tsering, Sam, Riba, Komri, puii, Zoreng, Zomawia, Eric, Singh, Y. Indibar, Suryawanshi, Amol Ratnakar, Kumar, Abhishek, Ganguly, Dipyaman, Goswami, Chandan, Choudhuri, Tathagata
Format: Artikel
Sprache:eng
Schlagworte:
Biological Sciences
Cancer
Human Genetics
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Zusammenfassung:Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2020.100937