Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-r...

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Veröffentlicht in:	Nature communications 2019-05, Vol.10 (1), p.2174-2174, Article 2174
Hauptverfasser:	Dobaño, Carlota, Sanz, Hèctor, Sorgho, Hermann, Dosoo, David, Mpina, Maximilian, Ubillos, Itziar, Aguilar, Ruth, Ford, Tom, Díez-Padrisa, Núria, Williams, Nana Aba, Ayestaran, Aintzane, Traore, Ousmane, Nhabomba, Augusto J., Jairoce, Chenjerai, Waitumbi, John, Agnandji, Selidji Todagbe, Kariuki, Simon, Abdulla, Salim, Aponte, John J., Mordmüller, Benjamin, Asante, Kwaku Poku, Owusu-Agyei, Seth, Tinto, Halidou, Campo, Joseph J., Moncunill, Gemma, Gyan, Ben, Valim, Clarissa, Daubenberger, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 49/1 631/250 631/250/255 631/250/590 631/326 82/1 Africa South of the Sahara Africans Antibodies Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Antibodies, Protozoan - isolation & purification Antibody Affinity - immunology Antigens, Protozoan - immunology Avidity C-Terminus Children Circumsporozoite protein Confidence intervals Disease transmission Domains Effectiveness Epitopes Epitopes - immunology Female Humanities and Social Sciences Humans Immunization Immunogenicity, Vaccine Immunoglobulin G Infant Infants Malaria Malaria vaccine Malaria Vaccines - immunology Malaria Vaccines - therapeutic use Malaria, Falciparum - blood Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Malaria, Falciparum - prevention & control Male multidisciplinary Plasmodium falciparum - immunology Protozoan Proteins - immunology Science Science (multidisciplinary) Treatment Outcome Vaccination Vaccine efficacy Vaccines Vacuna de la malària Vector-borne diseases
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Zusammenfassung:	RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination ( p
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-019-10195-z