P.24 Factors Associated with Premature Vascular Aging in Patients with Arterial Hypertension

Objectives Identification of factors associated with premature vascular aging in patients with arterial hypertension (AH). Methods The study included 61 patients (29 men, 32 women) with 1–2 grade AH without cardiovascular complications, aged 40 to 60 years, of which 28 (45.9%) had type 2 diabetes. The duration of AH was 5.0 [2.0; 10.0] years, type 2 diabetes - 2.0 [1.0; 4.0] years. The assessment of vascular stiffness using cardio-ankle vascular index (CAVI) and vascular age (VA) was performed by volumetric sphygmography (VaSera-1500). All patients were divided into 2 groups: with normal VA (the passport age corresponds to the VA, n = 35) and premature vascular aging (the VA is higher than the passport age, n = 26). Results There were no significant differences in gender, smoking, dyslipidemia, and the presence and duration of type 2 diabetes in the comparison groups. Significantly higher values of blood pressure (BP) were observed in the group of patients with premature vascular aging - 153.7 ± 26.2/95.3 ± 13.2 versus 137.9 ± 18.6/88.4 ± 13.3 mm Hg., higher duration of AH 10.0 [4.0; 13.0] vs. 3.0 [1.0; 8.0] years, higher blood urea level 5.7 [5.3; 6.8] vs. 4.5 [3.8; 5.8] mmol/l, increased CAVI average values on the right and on the left 8.8 [8.4; 9.4] vs. 7.4 [6.7; 7.9], intima-media thickness (IMT) of CCA (0.92 ± 0.13 vs. 0.80 ± 0.09 mm) and LV mass index (LVMI), 96.1 ± 21.8 vs. 86.1 ± 20.7 g/m 2 . Conclusion Premature vascular aging in patients with AH was associated with the degree and duration of hypertension, increased IMT, vascular stiffness [ 1 ], blood urea levels and LVMI.