Performance of Xpert MTB/RIF and sputum microscopy compared to sputum culture for diagnosis of tuberculosis in seven hospitals in Indonesia

Performance of Xpert MTB/RIF and sputum microscopy compared to sputum culture for diagnosis of tuberculosis in seven hospitals in Indonesia

Tuberculosis (TB) is a major public health concern in Indonesia, where the incidence was 301 cases per 100,000 inhabitants in 2020 and the prevalence of multi-drug resistant (MDR) TB is increasing. Diagnostic testing approaches vary across Indonesia due to resource limitations. Acid-fast bacilli (AF...

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Veröffentlicht in:Frontiers in medicine 2023-01, Vol.9, p.909198-909198
Hauptverfasser: Karuniawati, Anis, Burhan, Erlina, Koendhori, Eko Budi, Sari, Desvita, Haryanto, Budi, Nuryastuti, Titik, Gayatri, A A A Yuli, Bahrun, Uleng, Kusumawati, R Lia, Sugiyono, Retna Indah, Susanto, Nugroho Harry, Diana, Aly, Kosasih, Herman, Naysilla, Adhella Menur, Lokida, Dewi, Neal, Aaron, Siddiqui, Sophia, Lau, Chuen-Yen, Karyana, Muhammad
Format: Artikel
Sprache:eng
Schlagworte:
diagnosis
DST
Medicine
sputum culture
sputum microscopy
tuberculosis
Xpert MTB/RIF
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Zusammenfassung:Tuberculosis (TB) is a major public health concern in Indonesia, where the incidence was 301 cases per 100,000 inhabitants in 2020 and the prevalence of multi-drug resistant (MDR) TB is increasing. Diagnostic testing approaches vary across Indonesia due to resource limitations. Acid-fast bacilli (AFB) smear is widely used, though Xpert MTB/RIF has been the preferred assay for detecting TB and rifampicin resistance since 2012 due to higher sensitivity and ability to rapidly identify rifampicin resistance. However,
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2022.909198