Effect of long-acting polyethylene glycol recombinant human growth hormone dosages in pediatric practice: A pooled analysis of two phase IV randomized controlled trials

Effect of long-acting polyethylene glycol recombinant human growth hormone dosages in pediatric practice: A pooled analysis of two phase IV randomized controlled trials

According to the intention-to-treat principle, all randomized participants who used at least one dose of PEG-rhGH with efficacy data constituted the full-analysis set (FAS). [...]after 26 weeks of treatment, bone age assessment revealed no statistically significant differences between the two groups...

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Veröffentlicht in:Chinese medical journal 2024-09, Vol.137 (17), p.2125-2127
Hauptverfasser: Hou, Ling, Chen, Xuefeng, Du, Hongwei, Zhang, Jianping, Cheng, Xinran, Pan, Jiayan, Pan, Hui, Liao, Wei, Luo, Xiaoping, Fu, Junfen
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Age
Antigens
Child
Child, Preschool
Clinical Trials, Phase IV as Topic
Correspondence
Diabetes
Drug dosages
Female
Growth hormones
Hepatitis B
Human Growth Hormone - administration & dosage
Human Growth Hormone - therapeutic use
Humans
Insulin resistance
Insulin-like growth factors
Male
Mann-Whitney U test
Multicenter Studies as Topic
Polyethylene glycol
Polyethylene Glycols
Randomized Controlled Trials as Topic
Recombinant Proteins - administration & dosage
Recombinant Proteins - therapeutic use
Scoliosis
Thyroid gland
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Zusammenfassung:According to the intention-to-treat principle, all randomized participants who used at least one dose of PEG-rhGH with efficacy data constituted the full-analysis set (FAS). [...]after 26 weeks of treatment, bone age assessment revealed no statistically significant differences between the two groups. [...]PEG-rhGH proved efficacy and safety in children with GHD. Junfen Fu, Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China E-Mail: fjf68@zju.edu.cn; Xiaoping Luo, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China E-Mail: xpluo@tjh.tjmu.edu.cn How to cite this article:
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.1097/CM9.0000000000002954