Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections

Serologic testing remains crucial for Zika virus diagnosis. We found that urea wash in a Zika virus nonstructural protein 1 IgG ELISA distinguishes secondary dengue virus infection from Zika virus infection with previous dengue (sensitivity 87.5%, specificity 93.8%). This test will aid serodiagnosis...

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Veröffentlicht in:	Emerging infectious diseases 2018-07, Vol.24 (7), p.1355-1359
Hauptverfasser:	Tsai, Wen-Yang, Youn, Han Ha, Tyson, Jasmine, Brites, Carlos, Tsai, Jih-Jin, Pedroso, Celia, Drexler, Jan Felix, Balmaseda, Angel, Harris, Eva, Wang, Wei-Kung
Format:	Artikel
Sprache:	eng
Schlagworte:	B cells Dengue - diagnosis Dengue - immunology Dengue - virology Dengue virus Dengue Virus - classification Dengue Virus - immunology Dispatch Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Health aspects Humans Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin M - immunology Infection nonstructural protein 1 Serogroup serologic test Serologic Tests Urea Viral Nonstructural Proteins - immunology viruses Zika virus Zika Virus - classification Zika Virus - immunology Zika Virus Infection - diagnosis Zika Virus Infection - immunology Zika Virus Infection - virology
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Beschreibung
Zusammenfassung:	Serologic testing remains crucial for Zika virus diagnosis. We found that urea wash in a Zika virus nonstructural protein 1 IgG ELISA distinguishes secondary dengue virus infection from Zika virus infection with previous dengue (sensitivity 87.5%, specificity 93.8%). This test will aid serodiagnosis, serosurveillance, and monitoring of Zika complications in dengue-endemic regions.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2407.171170