Effects of garlic supplementation on non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials

[Display omitted] •The meta-analysis results showed that garlic powder could improve ALT, AST, LDL-c, TC and weight.•Preclinical trials indicated that treatment with garlic supplementation could ameliorate abnormal serum and liver lipid profiles.•Garlic supplementation are conducive to the prevention and treatment of NAFLD. This research was to estimate the curative effect of garlic supplement on non-alcoholic fatty liver disease (NAFLD), a total of and five clinical studies (randomized controlled trials (RCTs) and nine preclinical studies was included. The effect size of clinical trials was determined by standardized mean difference (SMD) with 95 % confidence interval (CI). Meta-analysis of enrolled 139 patients receiving garlic powder revealed a significant improvement of NAFLD, which include ALT: 95 % CI, −11.75 to − 6.24; P