Markedly Elevated Serum Aspartate Aminotransferase to Alanine Aminotransferase Ratio: A Clue to Hepatic Neoplasia

Inclusion criteria consisted of adult patients (≥18 years) who had evidence of hepatic neoplasia by imaging and/or histology, including hepatocellular carcinoma (HCC), hepatic metastases (HM) from extrahepatic malignancy, or hepatic lymphoma. 1 TABLEIndividual Characteristics of Patients With AST/ALT Ratio >5 (n = 45) Age (Years) Sex Cancer Etiology of Liver Disease Ethanol Intake Cirrhosis AST × ULN * ALT × ULN * AST/ALT Ratio ALP × ULN * TB × ULN * Platelet Count (×109/L) INR AFP (ng/mL) LDH × ULN * CK (U/L) Number of Lesions Vascular Invasion 58 F HCC Hepatitis B No No 42.8 1.4 31.1 1.8 0.5 245 1.06 5 14.2 94 Innumerable Yes 67 M HCC Cryptogenic No No 6.1 1.0 6.2 2.8 1.8 190 1.34 NA NA NA NA NA 61 M HCC Cryptogenic No No 3.6 0.4 10.2 1.4 1.0 504 0.93 114 1.0 8 Innumerable No 26 M HCC Cryptogenic No No 2.8 0.5 5.2 1.3 0.4 373 1.97 891 NA NA Single No 61 F HCC Hepatitis C No Yes 2.8 0.4 7.9 1.2 0.3 329 1.01 36,171 NA NA Innumerable No 50 M HCC Cryptogenic No Yes 7.4 1.0 7.2 4.4 3.2 142 1.21 NA NA 1,649 Innumerable Yes 42 M HCC Hepatitis C No Yes 64.0 6.4 10.0 3.1 16.2 41 10.11 NA 11.4 NA Innumerable No 60 M HCC Hepatitis B No Yes 9.7 1.6 6.3 4.8 7.5 347 1.18 321 1.3 NA 3 No 47 M HCC Cryptogenic No Yes 5.9 0.8 7.8 3.5 1.0 201 1.24 209 0.9 NA 2 No 38 M HCC Hepatitis B No Yes 14.2 0.5 29.8 1.1 23.0 115 1.67 NA NA NA Innumerable No 31 F HCC Hepatitis C No Yes 23.4 2.8 8.3 4.8 33.9 1,007 2.4 520 NA NA Single Yes 69 F HCC Hepatitis B/C No Yes 28.8 3.2 9.1 4.2 1.7 176 1.6 53,900 2.6 NA Single No 77 M HCC Hepatitis C No Yes 31.8 3.8 8.3 2.4 3.5 246 1.4 6,100 1.8 222 2 Yes 58 M HM None No No 26.3 4.0 6.6 1.7 3.7 45 4.43 1.7 5.5 54 Innumerable No 52 M HM None No No 23.8 3.1 7.6 9.5 15.5 35 5.15 3.2 4.7 NA Innumerable No 57 F HM None No No 52.0 4.0 13.0 6.2 2.5 205 2.14 4.1 22.2 661 Innumerable No 64 F HM None No No 31.3 4.7 6.7 11.1 5.3 70 1.13 NA 4.7 NA Innumerable No 29 F HM None No No 1.6 0.2 7.9 2.0 1.9 363 2.89 NA 1.1 NA Innumerable No 43 F HM None No No 8.3 1.0 8.1 6.2 1.2 173 1.38 NA NA 261 Innumerable No 64 F HM None No No 2.7 0.5 5.7 2.8 6.5 100 1.25 NA NA NA Single No 59 F HM None No No 5.1 0.6 8.9 3.0 0.5 299 1.25 NA 9.0 NA Innumerable No 60 F HM None No No 3.2 0.6 5.3 3.6 0.6 415 1.07 NA NA NA Single No 54 F HM None No No 5.1 1.0 5.3 2.4 12.9 287 1.34 NA NA NA Innumerable No 63 F HM None No No 8.8 1.4 6.2 8.6 0.7 403 1.23 NA NA 157 Innumerable No 62 M HM Hepatitis C No No 1.8 0.3 5.6 2.3 0.3 381 1.19 NA 4.1 NA Innumerable No 53 M HM None No No 8.0 1.1 7