Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD

Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD

•The presence of butyrogenic bacteria after the onset of acute GVHD associates with subsequent steroid-refractory GVHD or chronic GVHD.•Butyrate inhibits human colonic stem cells from forming an intact epithelial monolayer.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Blood advances 2019-10, Vol.3 (19), p.2866-2869
Hauptverfasser: Golob, Jonathan L., DeMeules, Martha M., Loeffelholz, Tillie, Quinn, Z.Z., Dame, Michael K., Silvestri, Sabrina S., Wu, Michael C., Schmidt, Thomas M., Fiedler, Tina L., Hoostal, Matthew J., Mielcarek, Marco, Spence, Jason, Pergam, Steven A., Fredricks, David N.
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease
Bacteria - pathogenicity
Graft vs Host Disease - complications
Humans
Stimulus Report
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•The presence of butyrogenic bacteria after the onset of acute GVHD associates with subsequent steroid-refractory GVHD or chronic GVHD.•Butyrate inhibits human colonic stem cells from forming an intact epithelial monolayer.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2019000362