Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia

There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in COVID-19 pneumonia has not been well investigated. Study was performed in 87 cases confirme...

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Veröffentlicht in:	Respiratory research 2020-07, Vol.21 (1), p.171-171, Article 171
Hauptverfasser:	Wu, Mei-Ying, Yao, Lin, Wang, Yi, Zhu, Xin-Yun, Wang, Xia-Fang, Tang, Pei-Jun, Chen, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers - blood Chest Chest CT China - epidemiology Cohort Studies Computed tomography Coronavirus Infections - blood Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronaviruses COVID-19 Dehydrogenase Dehydrogenases Diagnosis Disease Progression Disease transmission Female Follow-Up Studies Hospitalization Hospitals Humans Investigations L-Lactate dehydrogenase L-Lactate Dehydrogenase - blood Laboratories Lactate dehydrogenase Lactic acid LDH Male Medical imaging Middle Aged Pandemics Pneumonia Pneumonia, Viral - blood Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Predictive Value of Tests Radiography, Thoracic - methods Reproducibility of Results Retrospective Studies Risk Assessment Severity of Illness Index Tomography, X-Ray Computed - methods Viral diseases
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Zusammenfassung:	There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in COVID-19 pneumonia has not been well investigated. Study was performed in 87 cases confirmed by COVID-19 infection. The serum LDH levels were determined at diagnosis and follow-up visits. The evaluation of clinical response to therapy was based on chest CT scan. We selected the value of LDH around the data of chest CT scan (- 1 ~ + 1 day). At diagnosis, significant differences in LDH levels were found between non-severe and severe group (P
ISSN:	1465-993X 1465-9921 1465-993X 1465-9921
DOI:	10.1186/s12931-020-01427-8