Hospitalization in pregnancy due to human respiratory syncytial virus associated disease

Despite pregnancy being a state of physiologic immune alteration, it has not previously been described as a risk factor for hospitalization due to human respiratory syncytial virus (RSV). This retrospective case series describes two cases of hospitalization due to RSV associated illness in pregnancy. It remains to be determined if the current RSV surge is more dangerous to pregnant patients than those in seasons past. These cases support the importance of maintaining RSV on the differential for respiratory illness in pregnancy. •Human respiratory syncytial virus can cause acute respiratory distress and failure in pregnancy.•Human respiratory syncytial virus should be on the differential for upper respiratory tract symptoms in pregnancy.•The current 2022-2023 RSV surge may be of particular concern to pregnant patients.