ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES

ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES

The analgesic activity of the series of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones substituted in position 3 was studied. As a leader, it was revealed the compound 8 (3-propoxy-7-bromo-5-(2’-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one) with ED50 value of 0,030 ± 0,007 mg/kg, which also has dem...

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Veröffentlicht in:Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ 2014-11, Vol.18 (3(47)), p.28-37
Hauptverfasser: Pavlovsky, V. I., Kabanova, T. A., Khalimova, E. I., Andronati, S. A.
Format: Artikel
Sprache:eng
Schlagworte:
3-заміщені 1,4-бенздіазепіни
анальгезія
набряк
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Zusammenfassung:The analgesic activity of the series of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones substituted in position 3 was studied. As a leader, it was revealed the compound 8 (3-propoxy-7-bromo-5-(2’-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one) with ED50 value of 0,030 ± 0,007 mg/kg, which also has demonstrated in vivo anti-inflammatory activity in rats.
ISSN:2304-0947
2414-5963
DOI:10.18524/2304-0947.2013.3(47).31120