Aryl-capped lysine-dehydroamino acid dipeptide supergelators as potential drug release systems

Employing amino acids and peptides as molecular building blocks provides unique opportunities for generating supramolecular hydrogels, owing to their inherent biological origin, bioactivity, biocompatibility, and biodegradability. However, they can suffer from proteolytic degradation. Short peptides...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (19), p.11811
Hauptverfasser:	Oliveira, Carlos B. P., Pereira, Renato B., Pereira, David M., Hilliou, L., Castro, Tarsila Gabriel, Martins, J. A. R., Jervis, Peter John, Ferreira, Paula M. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Biocompatibility Biodegradability Biological activity Cell viability Ciprofloxacin Circular dichroism Controlled release critical gelation concentration Cytotoxicity dehydrodipeptides Delayed-Action Preparations Dichroism Dipeptides drug delivery systems Drug Liberation Dyes Emission microscopy Fluorescence spectroscopy Gelation Humans Hydrogels Hydrogels - chemistry Keratinocytes Low molecular weights Lysine Methylene Blue Molecular modelling Molecular weight Peptides Peptides - chemistry Proteolysis Rheological properties Rheology Scanning transmission electron microscopy Science & Technology Self-assembly Solvents Spectroscopy Spectrum analysis supramolecular hydrogels Sustained release Transmission electron microscopy
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Zusammenfassung:	Employing amino acids and peptides as molecular building blocks provides unique opportunities for generating supramolecular hydrogels, owing to their inherent biological origin, bioactivity, biocompatibility, and biodegradability. However, they can suffer from proteolytic degradation. Short peptides (
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms231911811