HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy

HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy

Background Cardiac fibrosis plays a crucial role in the pathogenesis of dilated cardiomyopathy (DCM). HE4 (human epididymis protein 4) is a secretory protein expressed in activated fibroblasts that exacerbates tissue fibrosis. In the present study, we investigated the clinical utility of HE4 measure...

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Veröffentlicht in:Journal of the American Heart Association 2021-08, Vol.10 (15), p.e021069-e021069
Hauptverfasser: Yamamoto, Masahiro, Hanatani, Shinsuke, Araki, Satoshi, Izumiya, Yasuhiro, Yamada, Toshihiro, Nakanishi, Nobuhiro, Ishida, Toshifumi, Yamamura, Satoru, Kimura, Yuichi, Arima, Yuichiro, Nakamura, Taishi, Takashio, Seiji, Yamamoto, Eiichiro, Sakamoto, Kenji, Kaikita, Koichi, Matsushita, Kenichi, Morimoto, Sachio, Ito, Takaaki, Tsujita, Kenichi
Format: Artikel
Sprache:eng
Schlagworte:
cardiorenal syndrome
HE4 (human epididymis protein 4)
left ventricular reverse remodeling
myofibroblast
Original Research
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Zusammenfassung:Background Cardiac fibrosis plays a crucial role in the pathogenesis of dilated cardiomyopathy (DCM). HE4 (human epididymis protein 4) is a secretory protein expressed in activated fibroblasts that exacerbates tissue fibrosis. In the present study, we investigated the clinical utility of HE4 measurement in patients with DCM and its pathophysiological role in preclinical experiments in vivo and in vitro. Methods and Results We measured serum HE4 levels of 87 patients with DCM. Endomyocardial biopsy expressed severe fibrosis only in the high HE4 group (P
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.120.021069