Small GTPases and Their Regulators: A Leading Road toward Blood Vessel Development in Zebrafish

Members of the Ras superfamily have been found to perform several functions leading to the development of eukaryotes. These small GTPases are divided into five major subfamilies, and their regulators can "turn on" and "turn off" signals. Recent studies have shown that this superf...

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Veröffentlicht in:	International journal of molecular sciences 2022-04, Vol.23 (9), p.4991
Hauptverfasser:	Urade, Ritesh, Chiu, Yan-Hui, Chiu, Chien-Chih, Wu, Chang-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Blood vessels Cancer Cell cycle Enzymes Eukaryotes Gene expression Genetic engineering GTP-binding proteins Ischemia Kinases Medical research Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Permeability Proteins Review Signal transduction small GTPases Stem cells Transcription factors vascular development and zebrafish Vascular endothelial growth factor Vascular system Veins & arteries Zebrafish Zebrafish - metabolism
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Beschreibung
Zusammenfassung:	Members of the Ras superfamily have been found to perform several functions leading to the development of eukaryotes. These small GTPases are divided into five major subfamilies, and their regulators can "turn on" and "turn off" signals. Recent studies have shown that this superfamily of proteins has various roles in the process of vascular development, such as vasculogenesis and angiogenesis. Here, we discuss the role of these subfamilies in the development of the vascular system in zebrafish.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23094991