COMPARISON OF VARIATION IN MEAN ARTERIAL BLOOD PRESSURE AFTER INDUCTION WITH SEVOFLURANE VERSUS PROPOFOL

Objective: To compare mean arterial pressure (MAP) variation after anaesthetic induction with inhalational sevoflurane versus intravenous propofol.Study Design: Randomized controlled study.Place and Duration of Study: The study was carried out at Combined Military Hospital Bahawalpur - a tertiary care hospital, after seeking permission from hospital ethical committee. The data was collected for 06 months starting, from Jul 2017 to Dec 2017.Material and Methods: In this study a total of 110 patients fulfilling the inclusion criteria were selected. Patients were randomly divided into two groups (55 in each group). Group A were anaesthetized with sevoflurane and group В with propofol. Mean arterial pressure measurement was carried out before induction, and then 02 minutes after induction. Difference of change in MAP from baseline was recorded both for sevoflurane and propofol. Digital monitor was used for MAP monitoring. The result of MAP was recorded in mmHg.Results: In our study, MAP at baseline was calculated as 102.62 ± 5.22 mmHg in group-A and 101.69 ± 5.57 mmHg in group-B, p-value was 0.36 showing insignificant difference at baseline and after 02 minutes of induction was calculated as 87.65 ± 3.49 mmHg in group-A and 84.11 ± 3.62 mmHg in group-B, p-value was 0.0001, a significant difference. Mean change in arterial pressure after 02 minutes of induction was calculated as 14.96 ± 6.89 mmHg in group-A and 17.58 ± 5.33 mm Hg in group-B, p-value was 0.0001, a significant difference.Conclusion: It is concluded that induction with sevoflurane is significantly better than induction with propofol for prevention of hypotension.