Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19

Neutrophil dysregulation is well established in COVID-19. However, factors contributing to neutrophil activation in COVID-19 are not clear. We assessed if N-formyl methionine (fMet) contributes to neutrophil activation in COVID-19. Elevated levels of calprotectin, neutrophil extracellular traps (NET...

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Veröffentlicht in:	Virulence 2023-12, Vol.14 (1), p.2218077-2218077
Hauptverfasser:	Kuley, Runa, Duvvuri, Bhargavi, Wallin, Jeffrey J., Bui, Nam, Adona, Mary Vic, O'Connor, Nicholas G., Sahi, Sharon K., Stanaway, Ian B., Wurfel, Mark M., Morrell, Eric D., Liles, W. Conrad, Bhatraju, Pavan K., Lood, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	clinical biomarkers COVID-19 Humans Leukocyte L1 Antigen Complex Methionine mitochondrial peptides N-formyl methionine peptide N-Formylmethionine - pharmacology Neutrophil Activation Neutrophils Peptides Racemethionine Research Paper systemic inflammation
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Zusammenfassung:	Neutrophil dysregulation is well established in COVID-19. However, factors contributing to neutrophil activation in COVID-19 are not clear. We assessed if N-formyl methionine (fMet) contributes to neutrophil activation in COVID-19. Elevated levels of calprotectin, neutrophil extracellular traps (NETs) and fMet were observed in COVID-19 patients (n = 68), particularly in critically ill patients, as compared to HC (n = 19, p
ISSN:	2150-5594 2150-5608
DOI:	10.1080/21505594.2023.2218077