Circulating biomarkers during progression to type 1 diabetes: A systematic review

Progression to type 1 diabetes (T1D) is defined in stages and clinical disease is preceded by a period of silent autoimmunity. Improved prediction of the risk and rate of progression to T1D is needed to reduce the prevalence of diabetic ketoacidosis at presentation as well as for staging participant...

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Veröffentlicht in:	Frontiers in endocrinology (Lausanne) 2023-02, Vol.14, p.1117076-1117076
Hauptverfasser:	Brenu, Ekua W, Harris, Mark, Hamilton-Williams, Emma E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoimmunity - genetics Biomarkers CD8-Positive T-Lymphocytes - metabolism Diabetes Mellitus, Type 1 - complications Disease Progression Endocrinology Humans islet autoimmunity miRNA systematic review type 1 diabetes Young Adult
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Beschreibung
Zusammenfassung:	Progression to type 1 diabetes (T1D) is defined in stages and clinical disease is preceded by a period of silent autoimmunity. Improved prediction of the risk and rate of progression to T1D is needed to reduce the prevalence of diabetic ketoacidosis at presentation as well as for staging participants for clinical trials. This systematic review evaluates novel circulating biomarkers associated with future progression to T1D. PubMed, Ovid, and EBSCO databases were used to identify a comprehensive list of articles. The eligibility criteria included observational studies that evaluated the usefulness of circulating markers in predicting T1D progression in at-risk subjects
ISSN:	1664-2392 1664-2392
DOI:	10.3389/fendo.2023.1117076