Nucleated red blood cells explain most of the association between DNA methylation and gestational age

Nucleated red blood cells explain most of the association between DNA methylation and gestational age

Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified...

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Veröffentlicht in:Communications biology 2023-02, Vol.6 (1), p.224-224, Article 224
Hauptverfasser: Haftorn, Kristine L., Denault, William R. P., Lee, Yunsung, Page, Christian M., Romanowska, Julia, Lyle, Robert, Næss, Øyvind E., Kristjansson, Dana, Magnus, Per M., Håberg, Siri E., Bohlin, Jon, Jugessur, Astanand
Format: Artikel
Sprache:eng
Schlagworte:
45/61
631/136/232/1473
631/208/176/1988
Age
Algorithms
Biology
Biomedical and Life Sciences
Blood
CpG islands
DNA Methylation
Epigenetics
Epigenomics
Erythroblasts
Erythrocytes
Erythropoiesis
Gestational Age
Life Sciences
Neonates
Phenotypes
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Zusammenfassung:Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (p Bonferroni
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-023-04584-w