A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy

A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy

A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a di...

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Veröffentlicht in:Brazilian Journal of Pharmaceutical Sciences 2020-01, Vol.56
Hauptverfasser: Karimi, Maryam, Karimian, Khashayar, Heli, Hossein
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer drug
Bioavailability
Breast cancer
Breast cancer cell
Cytotoxicity
Drug delivery systems
Efficiency
Glivec
Growth factors
Leukemia
Nanoemulsion
Nanoemulsions
Nanoparticles
PHARMACOLOGY & PHARMACY
Polyethylene glycol
Standard deviation
Surfactants
Targeted cancer therapy
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Zusammenfassung:A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902020000118973