Miniaturized solid-phase microextraction coupled with gas chromatography-mass spectrometry for determination of endocrine disruptors in drinking water

[Display omitted] •Miniaturized SPME (mini-SPME) is proposed for the first time for EDCs determination in drinking water samples.•The main parameters of mini-SPME were optimized for eight EDCs.•The mini-SPME method only requires a small amount of the sample.•The method was validated demonstrating good linearity, precision and accuracy. A simple and rapid method based on miniaturized solid-phase microextraction (mini-SPME) followed by gas chromatography–mass spectrometry was developed to identify eight endocrine disruptors (atrazine, diethylstilbestrol, hexestrol, estrone, estradiol, ethinylestradiol, norgestrel, and megestrel) in drinking water samples. Extraction parameters was optimized and further analyses was performed using them. The optimum temperature for the determination of endocrine disruptors in water was 80 °C; the optimum extraction and preincubation times were 60 and 20 min, respectively. The studied linear range of endocrine disruptors was 10.0–1000 μg mL−1. The limit of detection ranged from 0.020 to 0.087 μg mL−1. The correlation coefficient (r2) was 0.96–0.99. This research introduces a novel method for detecting analytes at extremely low concentrations, as well as the possibility of combining several detection technologies to give high-accuracy qualitative and quantitative determination of endocrine disruptors in aqueous samples.