High-Risk Features Are Prognostic in dMMR/MSI-H Stage II Colon Cancer

High-Risk Features Are Prognostic in dMMR/MSI-H Stage II Colon Cancer

High-risk features, such as T4 disease, bowel obstruction, poorly/undifferentiated histology, lymphovascular, perineural invasion, and 1, and older age. Adjuvant chemotherapy administration was associated with better OS, regardless of the high-risk features in dMMR/MSI-H (log-rank test, = 0.001) or...

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Veröffentlicht in:Frontiers in oncology 2021-10, Vol.11, p.755113-755113
Hauptverfasser: Mohamed, Amr, Jiang, Renjian, Philip, Philip A, Diab, Maria, Behera, Madhusmita, Wu, Christina, Alese, Olatunji, Shaib, Walid L, Gaines, Tyra M, Balch, Glen G, El-Rayes, Bassel F, Akce, Mehmet
Format: Artikel
Sprache:eng
Schlagworte:
adjuvant chemotherapy
cancer
colon
high risk
Oncology
stage II
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Zusammenfassung:High-risk features, such as T4 disease, bowel obstruction, poorly/undifferentiated histology, lymphovascular, perineural invasion, and 1, and older age. Adjuvant chemotherapy administration was associated with better OS, regardless of the high-risk features in dMMR/MSI-H (log-rank test, = 0.001) or not ( = 0.0006). When stratified by age, the benefit of chemotherapy was evident only in patients age ≥65 with high-risk features. High-risk features are prognostic in the setting of dMMR/MSI-H stage II CC. Adjuvant chemotherapy may improve survival specifically in patients ≥65 years and with high-risk features.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.755113