Microwave-Assisted Synthesis of Schiff Bases of Isoniazid and Evaluation of Their Anti-Proliferative and Antibacterial Activities

Three new Schiff bases of isoniazid were synthesized using microwave-assisted synthesis and conventional condensation with aromatic aldehydes. Synthesized compounds were characterized using elemental analysis, IR, NMR, and Mass spectroscopy. Synthesized compounds were evaluated for antiproliferative...

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Veröffentlicht in:	MolBank 2021-03, Vol.2021 (1), p.M1189
Hauptverfasser:	Al-Hiyari, Bayan Ahed, Shakya, Ashok K., Naik, Rajashri R., Bardaweel, Sanaa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aldehydes antibacterial antiproliferative Antiproliferatives Aromatic compounds Breast cancer Cancer therapies Cell cycle Chemical analysis Chemotherapy Drug resistance E coli Ethanol Imines Infrared analysis Infrared spectroscopy isoniazid MCF-7 cell lines microwave irradiation NMR Nuclear magnetic resonance Peptides Schiff base Spectrum analysis Synthesis
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Zusammenfassung:	Three new Schiff bases of isoniazid were synthesized using microwave-assisted synthesis and conventional condensation with aromatic aldehydes. Synthesized compounds were characterized using elemental analysis, IR, NMR, and Mass spectroscopy. Synthesized compounds were evaluated for antiproliferative activity against MCF-7 cell line. The IC50 values were from 125 to 276 µM. The compounds were also evaluated for antibacterial activity against Staphylococcus aureus and Escherichia coli. Results showed that the synthesized compounds produce significant antibacterial activity in vitro. Inhibition of compounds ranged from 13 to 18 mm.
ISSN:	1422-8599 1422-8599
DOI:	10.3390/M1189