Sex and menopause impact 31P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with 11C-PiB PET amyloid-beta load

Increasing evidence implicates sex and endocrine aging effects on brain bioenergetic aging in the greater lifetime risk of Alzheimer’s disease (AD) in women. We conducted 31 Phosphorus Magnetic Resonance Spectroscopy ( 31 P-MRS) to assess the impact of sex and menopause on brain high-energy phosphat...

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Veröffentlicht in:	Scientific reports 2022-12, Vol.12 (1), p.22087-13, Article 22087
Hauptverfasser:	Jett, Steven, Dyke, Jonathan P., Andy, Caroline, Schelbaum, Eva, Jang, Grace, Boneu Yepez, Camila, Pahlajani, Silky, Diaz, Ivan, Diaz Brinton, Roberta, Mosconi, Lisa
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/245/1628 631/1647/245/2092 631/378 631/378/1689/1283 631/378/2612 631/443/494/4038 631/45/776 631/80/642/333 692/499 692/53/2423 Adaptation Adenosine triphosphate Aging Alzheimer's disease Apolipoprotein E ATP Bioenergetics Cortex (frontal) Females Humanities and Social Sciences Hysterectomy Magnetic resonance spectroscopy Menopause Middle age Mitochondria multidisciplinary Neurodegenerative diseases Ovariectomy Phosphocreatine Phosphodiesters Phospholipids Phosphomonoesters Positron emission tomography Post-menopause Premenopause Science Science (multidisciplinary) Sex Spectroscopy Spectrum analysis Temporal lobe
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Zusammenfassung:	Increasing evidence implicates sex and endocrine aging effects on brain bioenergetic aging in the greater lifetime risk of Alzheimer’s disease (AD) in women. We conducted 31 Phosphorus Magnetic Resonance Spectroscopy ( 31 P-MRS) to assess the impact of sex and menopause on brain high-energy phosphates [adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi)] and membrane phospholipids [phosphomonoesters/phosphodiesters (PME/PDE)] in 216 midlife cognitively normal individuals at risk for AD, 80% female. Ninety-seven participants completed amyloid-beta (Aβ) 11 C-PiB PET. Women exhibited higher ATP utilization than men in AD-vulnerable frontal, posterior cingulate, fusiform, medial and lateral temporal regions (p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-26573-5