Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia

The ACE and MMP-3 loci are involved in the vascular remodeling, increased intima media thickness and arterial stiffness associated with hypertension. We determined ACE I/D and MMP-3 5A/6A gene polymorphisms in 231 Caucasian males (126/105, hypertensive/normotensive). Owing to age-related differences hypertension, the sample was truncated with respect to age (the cut-off point was the age of 40). Our results indicate that ACE I/D and MMP-3 5A/6A polymorphisms are likely to be risk factors for hypertension in men from Serbia = 40 years of age. In the same group, the combined effect of DD/6A+ genotypes on hypertension was more pronounced than their separate effect. . ACE i MMP-3 su ukljuceni u procese remodelovanja zida krvnih sudova, zadebljanja intima-medije i gubitka elasticnosti arterija koji su povezani sa hipertenzijom. Utvrdjivanje genotipova polimorfizama I/D i 5A/6A u genima za ACE i MMP-3 je uradjeno na uzorku od 231 muskarca, Kavkazoida (126/105, hipertenzivni/normotenzivni). Obzirom na povezanost nastanka hipertenzije sa godinama starosti ispitivana populacija je podeljena u dve starosne grupe (do i preko 40-e godine starosti). Nasi rezultati ukazuju da su polimorfizmi u genima za ACE (I/D) i MMP-3 (5A/6A) moguci faktori rizika za nastanak hipertenzije kod muskaraca = 40 godina starosti u populaciji Srbije. U istoj starosnoj grupi zajednicki uticaj genotipova DD/6A+ na nastanak hipertenzije je bio veci od njihovog pojedinacnog uticaja. .