Exploring the Impact of Single-Nucleotide Polymorphisms on Translation

Exploring the Impact of Single-Nucleotide Polymorphisms on Translation

Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mut...

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Veröffentlicht in:Frontiers in genetics 2018-10, Vol.9, p.507-507
Hauptverfasser: Robert, Francis, Pelletier, Jerry
Format: Artikel
Sprache:eng
Schlagworte:
eIF4F
genetic variant
Genetics
ribosome recruitment
SNP
translation initiation
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Beschreibung
Zusammenfassung:Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mutations on gene expression is still in its infancy. Here, we provide key examples to help understand how mutations present in genes can affect translational output.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2018.00507