Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was cov...

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Veröffentlicht in:Molecular therapy. Nucleic acids 2013, Vol.2 (6), p.e100-e100, Article e100
Hauptverfasser: Costa, Pedro M, Cardoso, Ana L, Mendonça, Liliana S, Serani, Angelo, Custódia, Carlos, Conceição, Mariana, Simões, Sérgio, Moreira, João N, Pereira de Almeida, Luís, Pedroso de Lima, Maria C
Format: Artikel
Sprache:eng
Schlagworte:
chlorotoxin
glioblastoma
liposome
miR-21
Original
stable nucleic acid lipid particle
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Zusammenfassung:The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was covalently coupled to liposomes encapsulating antisense oligonucleotides (asOs) or small interfering RNAs (siRNAs). The resulting targeted nanoparticles, designated CTX-coupled stable nucleic acid lipid particles (SNALPs), exhibited excellent features for in vivo application, namely small size (
ISSN:2162-2531
2162-2531
DOI:10.1038/mtna.2013.30