Oxidized low‐density lipoproteins as a novel risk factor and therapeutic target for ACM

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease involving arrhythmia in young adults accompanied by structural changes at later stages. In this issue of EMBO Molecular Medicine , Sommariva et al (2021) identified a positive correlation between circulating levels of oxidized low‐density lipoproteins (oxLDL) and ACM disease penetrance, which contributes to fibro‐fatty cardiac remodeling via the oxLDL/CD36/PPARγ axis. These data identify oxidized low‐density lipoproteins as a risk factor for ACM and uncover a novel therapeutic intervention option to block disease pathogenesis. Graphical Abstract E. van Rooij & colleagues discuss the study by Sommariva et al , in this issue of EMBO Mol Med , that identifies a positive correlation between oxLDL circulating levels and ACM disease penetrance, and uncovers a novel therapeutic intervention option to block disease pathogenesis.