MicroRNA profiling as a novel diagnostic tool for identification of patients with inflammatory and/or virally induced cardiomyopathies

MicroRNA profiling as a novel diagnostic tool for identification of patients with inflammatory and/or virally induced cardiomyopathies

Aims MicroRNAs (miRNAs) might be used as prospective biomarkers for the identification of unexplained heart failure caused by a viral and/or inflammatory process. The aim of this study was to identify and to evaluate prognostic miRNAs in serum of patients with inflammatory heart diseases diagnosed b...

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Veröffentlicht in:ESC Heart Failure 2021-02, Vol.8 (1), p.408-422
Hauptverfasser: Aleshcheva, Ganna, Pietsch, Heiko, Escher, Felicitas, Schultheiss, Heinz‐Peter
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviruses
Biomarkers
Biopsy
Blood & organ donations
Cardiomyopathy
Cardiovascular disease
Connective tissue
DCM
Deoxyribonucleic acid
DNA
Ejection fraction
Genomes
Heart failure
Inflammation
MicroRNAs
MiRNA
Myocarditis
Original
Original s
Virus
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Zusammenfassung:Aims MicroRNAs (miRNAs) might be used as prospective biomarkers for the identification of unexplained heart failure caused by a viral and/or inflammatory process. The aim of this study was to identify and to evaluate prognostic miRNAs in serum of patients with inflammatory heart diseases diagnosed by endomyocardial biopsies. Methods and results After TaqMan® OpenArray® screening of 754 unique circulating miRNAs in serum of biopsy‐proven patients [184 patients with inflammatory and/or virally induced myocardial diseases (DCMi), 25 patients with dilated cardiomyopathy (DCM), and 25 healthy donors], we identified seven miRNAs of interest (P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13090