A novel water-based anti-aging suncare formulation provides multifaceted protection and repair against environmental aggressors: evidence from in vitro, ex vivo, and clinical studies

Ultraviolet (UV) radiation is an established cause of skin aging, and the role of pollution is increasingly acknowledged. In this study, we evaluated the efficacy of an antipollution and anti-aging suncare product in in vitro, ex vivo, and clinical studies. We assessed 1) sunburn cell (SBC) and cyclobutane pyrimidine dimer (CPD) formation and gene expression profile in reconstructed human epidermis following solar irradiation, 2) malondialdehyde (MDA) level, Nrf2 immunostaining, and genetic expression in skin explants exposed to pollution, 3) carbon particle adhesion to healthy forearm skin in a clinical study, and 4) skin firmness, elasticity, and pigmentation spots in healthy women following 56 days of application. 1) The product fully protected against CPD formation, and provided a high protection against SBC formation, with levels close to non-irradiated samples. Expression of genes encoding pro-inflammatory and oxidative stress response markers was lower in product-treated than untreated skin. 2) Compared with pollution-exposed untreated controls, product-treated skin had 23% lower MDA levels (