High immune cytolytic activity in tumor‐free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

High immune cytolytic activity in tumor‐free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A (GZMA) and perforin (PRF1) mRNA levels, we investigated imm...

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Veröffentlicht in:The journal of pathology. Clinical research 2019-10, Vol.5 (4), p.240-247
Hauptverfasser: Gu, Xiaolian, Boldrup, Linda, Coates, Philip J, Fahraeus, Robin, Wang, Lixiao, Wilms, Torben, Norberg‐Spaak, Lena, Sgaramella, Nicola, Nylander, Karin
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Biopsy
Cancer
CD8 antigen
Cytolytic activity
Cytotoxicity
Enumeration
Gene expression
Immunoreactivity
Immunotherapy
Lymphocytes
Lymphocytes T
Medical prognosis
Metastases
oral tongue
Original
Patients
Perforin
prognosis
Squamous cell carcinoma
Tongue
Tumors
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Zusammenfassung:Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A (GZMA) and perforin (PRF1) mRNA levels, we investigated immunoreactivity in tumor and/or tumor‐free tongue tissue samples from 31 patients with squamous cell carcinoma of the oral tongue and 14 healthy individuals (control tongue tissues). We found significantly altered immune cell compositions (p 
ISSN:2056-4538
2056-4538
DOI:10.1002/cjp2.138