Physicochemical characterization tungsten oxide modified hydroxyapatite embedded into polylactic acid nanocomposite for biomedical applications

•HAP/WO3/GO has been fabricated for biomedical applications.•The triple ingredient composite HAP/WO3/GO exhibits an average grain size of 22.8 nm.•HAP/WO3/GO exhibits an anti-microbial activity around 26.4 ± 2.1 and 23.5 ± 1.3 mm against E. coli and S. aureus. To compensate for the feeble antimicrobial potential of hydroxyapatite (HAp), the compound has been incorporated into different nanocomposites (NCs) in addition to powder and fibrous structure. Hydroxyapatite (HAp)/tungsten oxide/graphene oxide (GO) ternary nanocomposite introduces a significant enhance in the cell viability to 96.7 ± 3% towards the osteoblast cells. The chemical compositions were approved by various analytical techniques such as XRD, FTIR, XPS, and EDS. TEM shows well-defined, rod-like HAp grains. The triple ingredient HAp/WO3/GO nano-composite exhibits an 22.8 nm grain size. FESEM introduces grain shape deviation via changing HAp additives from semi-spherical to needle-like with macro-porous structure within the composite of HAp/WO3/GO. Moreover, compatibility of ternary nanocomposite inside the PLA environment led to decrease in the contact angle of the nanofibrous structure reached 16.5 ± 4.4°. The combination of HAp and organic/inorganic elements might represent a good characterization for the target biological applications. HAp/WO3/GO composite exhibits a significant improvement in anti-microbial activity to be around 85.6 ± 1.6 % and 110.1 ± 2.0 % in for E. coli and S. aureus.