Necrostatin-1 attenuates early brain injury after subarachnoid hemorrhage in rats by inhibiting necroptosis

Necrostatin-1 attenuates early brain injury after subarachnoid hemorrhage in rats by inhibiting necroptosis

Necroptosis is programmed cell death that has been recently proposed and reported to be involved in several neurologic diseases. However, the role of necroptosis in early brain injury after subarachnoid hemorrhage (SAH) is still unknown. The purpose of this study was to investigate whether necroptos...

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Veröffentlicht in:Neuropsychiatric disease and treatment 2017-01, Vol.13, p.1771-1782
Hauptverfasser: Chen, Fuxiang, Su, Xingfen, Lin, Zhangya, Lin, Yuanxiang, Yu, Lianghong, Cai, Jiawei, Kang, Dezhi, Hu, Liwen
Format: Artikel
Sprache:eng
Schlagworte:
Aneurysms
Apoptosis
Brain injuries
Care and treatment
Cell death
Health aspects
Kinases
Necroptosis
Necroptosis
Necrostatin-1
Neuroprotection
Original Research
Proteins
Rodents
Stroke
Subarachnoid hemorrhage
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Zusammenfassung:Necroptosis is programmed cell death that has been recently proposed and reported to be involved in several neurologic diseases. However, the role of necroptosis in early brain injury after subarachnoid hemorrhage (SAH) is still unknown. The purpose of this study was to investigate whether necroptosis was involved in SAH-induced early brain injury, and to assess the possible neuroprotective effect of necrostatin-1 using an endovascular perforation rat model of SAH. Our results showed that the expression levels of necroptosis-related proteins including RIP1, RIP3 and MLKL in the basal cortex all increased at 3 hours after SAH (
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S140801